Comparative Molecular Genetic Characteristics of <i>Mycobacterium tuberculosis</i> Cultures Isolated in the European Part of the Russian Federation in 1998–2003 and 2016–2021

The objective: to evaluate changes in detection frequency of Mycobacterium tuberculosis the main phylogenetic lines with various genetic determinants resistance rifampicin, isoniazid and fluoroquinolones 1998–2003 2016–2021. Subjects Methods. 965 mycobacterial cultures were studied, those isolated from pulmonary patients spoligotypes presence gene mutations associated isoniazid, determined. Results. In 2016–2021 versus 1998–2003, incidence Beijing subline increased 50,72% 64,60%. Within Euro-American line, LAM9 decreased (from 40,00% 14,81%), while T1 27,11% 41,36%). MDR genotype rpoB531_Ser->Leu + katG315_Ser-> Thr [1] was selected. genotypic detected only 2016–2021, preXDR significantly more common compared line (21,67% vs. 3,73%, p <0,05).